Bennie George

Creative Bioarray has deep expertise in the profiling, identification and structural characterization of metabolites in vitro and in vivo. We use advanced technology and software for accurate, reliable metabolite identification and structural characterization. In addition, synthetic chemistry services are available to undertake synthesis of metabolites, reference standards, and internal standards to aid in method development and metabolite identification.

Creative Bioarray offers a large menu of cell-based NR assays to examine the effects of drug candidates on nuclear receptor activity. We offer more than 20 different cellular assays that monitor receptor activation by either nuclear translocation or NR co-activator interaction. If you have any special requirements in nuclear receptor screening, please feel free to contact us. We are looking forward to working together with your attractive projects.

Cell dissociation is a crucial process in biological research, particularly in cell culture, tissue engineering, and regenerative medicine. The ability to successfully isolate and harvest cells from tissues is essential for a variety of applications, including drug testing, genetic studies, and the development of cell-based therapies. This article explores the types, mechanisms, and applications of cell dissociation enzymes and reagents, highlighting their importance in modern biological research.

The success of any ion channel research program involves complex decisions that require specific expertise to address the complexities of these difficult biological targets. At Creative Bioarray, we have a team dedicated to helping you identify these choices, and we can work with you from determining the right detection format (binding and/or functional) and platform up to the data interpretation. From single-cell manual patch clamp (the gold standard) to high-throughput 384-well automated electrophysiological instruments, we have the capabilities to utilize platforms and strategies to deliver

Formalin-fixed paraffin-embedded (FFPE) tissue specimens are mainly used by the medical community and researchers to preserve biopsy samples in formaldehyde and then embed them into paraffin wax blocks. This process preserves the proteins and structures of the tissue. After storing it into a block, thin slices of the FFPE block can be made and is then mounted on a microscope slide to enable examination.

Immortalized Human Ovarian Epithelial Cells-SV40 have been obtained immortalizing Human Primary Ovarian Epithelial Cells with LentiSV40 Lentivirus. Immortalized cells were controlled passaging side by side with the primary cells. Primary cells go into senescence after the 3rd passage while the SV40tranduced cells go beyond 30 passages.

Immortalized Human Hepatocytes-SV40 from Creative Bioarray were developed from human tissues transduced with a lentiviral expression vector containing the SV40T gene. The cell line was continuously cultured for more than 30 passages without showing signs of growth retardation or replicative senescence.

Human Tenocytes are isolated from the patellar or Achilles tendon. The cells are isolated either by centrifugal force following enzymatic treatment or from an explants culture. Human Tenocytes are a useful tool in the study of regenerative medicine and other potential cellular therapies.

Bovine ovary paraffin sections are made of freshly harvested tissues, fixed in 10% neutral buffered formalin, and processed for paraffin embedding. Paraffin blocks are sectioned at a thickness of 5 microns and mounted on positively charged slides.

Bovine prostate paraffin sections are made of freshly harvested tissues, fixed in 10% neutral buffered formalin, and processed for paraffin embedding. Paraffin blocks are sectioned at a thickness of 5 microns and mounted on positively charged slides.

Bovine salivary, parotid paraffin sections are made of freshly harvested tissues, fixed in 10% neutral buffered formalin, and processed for paraffin embedding. Paraffin blocks are sectioned at a thickness of 5 microns and mounted on positively charged slides.

Bovine salivary, submaxillary paraffin sections are made of freshly harvested tissues, fixed in 10% neutral buffered formalin, and processed for paraffin embedding. Paraffin blocks are sectioned at a thickness of 5 microns and mounted on positively charged slides.

Induced Pluripotent Stem Cells (iPSCs) are a type of stem cell generated by reprogramming adult cells, such as skin or blood cells, to possess characteristics similar to embryonic stem cells. This process typically involves introducing specific key reprogramming genes (OCT4, KLF4, SOX2, cMYC, NANOG, and LIN28) into the adult cells, enabling them to regain pluripotency.

In the field of cancer research and drug development, traditional two-dimensional (2D) cell culture technology has long been widely used for drug screening and other experiments. Although this method is easy to use and cost-effective, it fails to effectively simulate the complex environment of tumors in vivo. Real tumors grow in three dimensions, with specific tissue architecture and cell-to-cell interactions. As a result, the findings obtained from 2D cultures often do not correlate with actual clinical outcomes, leading to a high failure rate of drugs in clinical trials. In contrast, three-dimensional (3D) model technology has demonstrated significant advantages in drug development and is gradually becoming a research hotspot.

Protein phosphorylation is an important post-translational modification (PTM) that controls numerous cellular functions, including the cell cycle, differentiation, and metabolism. Phosphate molecules are transferred from molecules like ATP to amino acids on proteins, such as serine, threonine, or tyrosine. This modification is widespread-about 30% of all proteins in eukaryotic cells. These dynamic changes can modify protein activity, interactions, and stability, ultimately affecting signaling networks and cellular responses. Failures in phosphorylation are linked to a diverse array of diseases

Creative Bioarray provides a cGMP-compliant Vero cell bank by following the industry-standard cell bank system to help our customers worldwide. By using cGMP Vero cell banking services, our clients can avoid cumbersome and time-intensive production of their cell bank and eliminate associated risks and costs. Thus, our clients can immediately start the cGMP Vero cell bank according to a fully tested manufacturing workflow.

Creative Bioarray provides a cGMP-compliant HEK293 cell bank by following the industry-standard cell bank system to help our customers worldwide. We have dedicated cell bank manufacturing scientists and quality professionals who create custom production processes for high-quality cell banks. Before cGMP manufacturing, we demonstrate key process parameters and quality attributes to our customers in a pilot or engineering.

Creative Bioarray provides a cGMP-compliant CHO cell bank by following the industry-standard cell bank system to help our customers worldwide. Our platform is equipped with cGMP production facilities, and extensive technical and regulatory expertise to support our clients' research. We also have a wealth of experience and knowledge and will advise on the most appropriate and cost-effective testing strategy to meet scientific and regulatory requirements.

Evaluating the potential side effects of human pharmaceuticals on the immune system should be incorporated into standard drug development process. Toxicity to the immune system includes inhibition or enhancement of the immune response. Inhibiting the immune response can result in a decrease in host resistance to infectious agents or tumor cells, while enhanced immune response can exacerbate autoimmune diseases or allergies. Currently, the assessment of immunotoxic effects depends on different animal models. With a few exceptions, the immune system of humans and experimental animals are very similar. Most drugs that inhibit the immune system in humans produce similar results in rodents, and the mechanisms for immunosuppressive action are similar.

High Throughput Screening (HTS) is a drug discovery process that allows automated detection of large numbers of chemical and/or biological compounds for a specific biological target. It speed up target analysis, as large scale compound libraries can be quickly screened in a cost-effective way. HTS should be seen as a fast scan of biological processes by which compounds with poor or no effects can be rapidly excluded from the analysis pipeline.